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Skin Barrier
Assessment

Advancing Skin Barrier Science
The skin barrier plays a crucial role in protecting against environmental stressors and maintaining hydration. Nevisense enables objective, non-invasive assessment of barrier function in research settings.

Why Nevisense

  • SciBase Golden Bullet
    Objective, quantitative skin barrier assessment
  • SciBase Golden Bullet
    Track treatment efficacy and barrier recovery over time
  • SciBase Golden Bullet
    Non-invasive, painless and repeatable measurements

Quantitative skin health data

Using EIS, Nevisense measures subtle changes in the skin’s bioelectrical properties that reflect skin structure and barrier integrity. This provides quantitative data for studying conditions such as atopic dermatitis and dry skin, as well as monitoring barrier recovery (Ref. 1).

Measurements across multiple clinically relevant frequencies provide information associated with:
• Tissue structure and organization
• Cell membrane integrity
• Cellular orientation
• Tight junction integrity
• Moisture compartmentalization
• Water loss
• Extracellular composition
• Changes associated with barrier disruption and inflammation

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Scibase_254A0850_Foto Liza Simonsson croped

Tracking treatment efficacy

Clinicians and researchers can monitor how therapies impact barrier status over time. Nevisense has shown potential in multiple barrier-related indications and is currently being used in research areas such as:
• Flare prediction
• Disease severity
• Disease prediction
• Ex vivo testing
• Treatment efficacy

HEAR FROM SCIENTISTS

"I work every day with the management of different allergic diseases in children, and it is a growing problem. Allergic diseases have a natural progression, with Atopic dermatitis being the first to manifest, often already in infancy, followed by other allergic diseases, such as food allergy and allergic asthma. The ability to identify these children early will help to develop preventive strategies for allergic diseases, and Nevisense is an extremely promising method that has potential for early prediction of those children."

DR. CAROLINE RODUIT PD Dr. med., PhD, University of Zurich | UZH · Children’s Hospital of Eastern Switzerland.
Caroline Roduit
allergy

Supporting dermatology and allergy research
Nevisense provides objective, quantitative data on skin-barrier integrity. It supports researchers and healthcare professionals studying how skin conditions, environmental exposures and treatments affect barrier function over time (Ref. 2).

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Non-invasive and repeatable testing
Nevisense measurements are non-invasive and easy to repeat, ideal for longitudinal studies and sensitive patient populations such as infants (Ref. 3).

Discover how Nevisense can support your research

Book a personalized demonstration, or contact SciBase for more information on Nevisense in a research setting.
References:
1. Changes in skin barrier integrity by electrical impedance spectroscopy during dupilumab treatment on a child with severe atopic dermatitis, Elif Yaycı , Işıl Ezelsoy , Beliz Su Gündoğdu , Betül Büyüktiryaki , Cansın Saçkesen, The Turkish Journal of Pediatrics 2024; Early View: 1-6 https://doi.org/10.24953/turkjpediatr.2024.4902
2. Household laundry detergents disrupt barrier integrity and induce inflammation in mouse and human skin, Arturo O. Rinaldi, Manru Li, Elena Barletta, Paolo D’Avino, Duygu Yazici, Yagiz Pat, Siobhan Ward, Daniel Burla, Ge Tan, Nima Askary, Rasmus Larsson, Jeremy Bost, Huseyn Babayev, Raja Dhir, Nicolas Gaudenzio, Mubeccel Akdis, Kari Nadeau, Cezmi A. Akdis, Yasutaka Mitamura
3. Elevated Neonatal Electrical Impedance Spectroscopy Measurements Are Associated With Atopic Dermatitis in High-Risk Infants" is published in the journal Allergy and can be found through this link: https://onlinelibrary.wiley.com/doi/10.1111/all.70402