Skin Barrier studies
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Backed by clinical evidence
Nevisense originated from research at Karolinska Institutet in Sweden. Today, the technology is supported by a growing body of dermatological research, cosmetic testing and product development worldwide.
Skin Barrier Function Assessment: Electrical Impedance Spectroscopy Is Less Influenced by Daily Routine Activities Than Transepidermal Water Loss, Lisa Huygen, Pauline Marie Thys, Andreas Wollenberg, Jan Gutermuth, Inge Kortekaas Krohn, Ann Dermatol. 2024 Apr;36(2):e15, https://doi.org/10.5021/ad.23.052, pISSN 1013-9087·eISSN 2005-3894
Electrical impedance spectroscopy detects skin barrier dysfunction in childhood atopic dermatitis, Mari Sasaki, Mathilda Sundberg, Remo Frei, Ruth Ferstl, Kristina N. Heye, Erik P. Willems, Cezmi A. Akdis, Roger Lauener, CK-CARE Study Group, Caroline Roduit. https://onlinelibrary.wiley.com/doi/full/10.1111/all.15895
Household laundry detergents disrupt barrier integrity and induce inflammation in mouse and human skin, Arturo O. Rinaldi, Manru Li, Elena Barletta, Paolo D’Avino, Duygu Yazici, Yagiz Pat, Siobhan Ward, Daniel Burla, Ge Tan, Nima Askary, Rasmus Larsson, Jeremy Bost, Huseyn Babayev, Raja Dhir, Nicolas Gaudenzio, Mubeccel Akdis, Kari Nadeau, Cezmi A. Akdis, Yasutaka Mitamura,https://onlinelibrary.wiley.com/doi/full/10.1111/all.15895
Electrical impedance spectroscopy for the characterization of skin barrier in atopic dermatitis, Rinaldi, Korsfeldt, Ward, Burla, Dreher, Gautschi, Stolpe, Tan, Bersuch, Melin, Askary Lord, Grant, Svedenhag, Tsekova, Schmid‐Grendelmeier, Möhrenschlager, Renner, Akdis, European Journal of Allergy and Clinical Immunology, April 2021, https://doi.org/10.1111/all.14842
Skin hydration dynamics investigated by electrical impedance techniques in vivo and in vitro Morin, Ruzgas, Svedenhag, Anderson, Ollmar, Engblom, Björklund, Scientific reports Oct 2020 10:17218, doi.org/10.1038/s441598-020-73684-y
Electrical Impedance Spectroscopy as a safe and efficient tool for the evaluation of epithelial barrier, Rinaldi AO, Ward S, Burla D, Gautschi M, Stolpe B, Johansson A, Melin D, Grant S, Svedenhag P, Tsekova K, Möhrenschlager M, Renner E, Akdis C. , e-Poster Gordon Research Conference Jan 2020
Direct Assessment of skin epithelial barrier by electrical impedance spectroscopy, Rinaldi AO, Morita H, Wawrzyniak P, Dreher A, Grant S, Svedenhag P, Akdis CA, Allergy 2019 Apr 16, DOI: 10.1111/all.13824
Facts and artefacts regarding correlation between skin electrial impedance spectroscopy (EIS) and blood glucose Ollmar S, Nicander I, Åberg P, Bolinder J. XV Int. Conf. on Electrical Bio-Impedance & XIV Conf. on Electrical Impedance Tomography. IOP Publishing, Journal of Physics: Conference Series 434 (2013) 012071.
Bioimpedance as a noninvasive method for measuring changes in skinÅberg P, Nicander I, Ollmar S. XV In: Handbook of Non-Invasive Methods and the Skin, 2nd ed – pp 345-350. Serup, Jemec, Grove. CRC Press 2006.
Within and beyond the skin barrierOllmar S, Nicander I. In: Bioengineering of the skin – Water and the stratum corneum, 2nd ed., pp 335-350. Fluhr, Elsner, Berardesca, Maibach (Eds.). CRC Press 2005.
Effects of pretreatment with a urea-containing emollient on nickel allergic skin reactions abstract, Kuzmina N, Nyrén M, Lodén M, Edlund F, Emtestam L. Acta Dermato-Venereologica 2005; 85: 9-12
Effects of pre-treatment with a urea-containing emollient on nickel allergic skin reactions Kuzmina N, Nyrén M, Lodén M, Edlund F, Emtestam L, Nicander I, Ollmar S. Proc XII Intern Conf on Electrical Bio-Impedance & V Electrical Impedance Tomography, Gdansk (PL), June 20-24, 2004, 111-113. ISBN 83-917681-6-3
Skin bioimpedance, Ollmar S, Nicander I, Åberg P. Proc XII Intern Conf on Electrical Bio-Impedance, Gdansk (PL), June 20-24, 2004, 343-346. ISBN 83-917681-6-3>br>
Blood glucose modulates impedance levelBirgersson U, Neiderud F, Åberg P, Ollmar S. Proc XII Intern Conf on Electrical Bio-Impedance & V Electrical Impedance Tomography, Gdansk (PL), June 20-24, 2004, 153-156. ISBN 83-917681-6-3.
Biophysical aspects of contact dermatitis and its prevention abstract, Kuzmina N. Karolinska Institutet (thesis), Stockholm 2004
Clinically normal atopic skin versus non-atopic skin as seen through electrical impedance abstract, Nicander I, Ollmar S. Skin Res Technol 2004; 10: 178-183
Assessment of irritant skin reactions using electrical impedance – a comparison between 2 laboratories abstractKuzmina N, Duval C, Johnsson S, Boman A, Lindberg M, Emtestam L. Contact dermatitis 2003; 49(1): 26-31
Basal electrical impedance in relation to sodium lauryl sulphate-induced skin reactions – a comparison of patients with eczema and healthy controls abstractKuzmina N, Hagströmer L, Nyrén M, Emtestam L. Skin Res Technol 2003; 9: 357-362
Betaine in oral hygiene with special attention to dry and sensitive mucosa (thesis), Rantanen I. Annales Universitatis Turkuensis 559, Turku, Finland 2003
The effects of two sodium lauryl sulphate-containing toothpastes with and without betaine on human oral mucosa in vivo abstract, Rantanen I, Jutila K, Nicander I, Tenovuo J, Söderling E. Swed Dent J 2003; 27: 31-34
Electrical impedance as a potential tool to distinguish between allergic and irritant contact dermatitis abstract, Nyren M, Kuzmina N, Emtestam L. J Am Acad Dermatol 2003;48: 394-400
The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively abstract, Nicander I, Åberg P, Ollmar S. Skin Res Technol 2003; 9: 43-49
The ability of betaine to reduce the irritating effects of detergents assessed visually, histologically and by bioengineering methods abstract, Nicander I, Rantanen I, Lundh Rozell B, Söderling E, Ollmar S. Skin Res Technol 2003; 9: 50-58
Non-invasive detection of sub-clinical skin reactionsOllmar S. Proc of the 2nd International Workshop on Biological Effects of Electromagnetic Fields, Rhodes (GR), 7-11 Oct 2002, vol I: 46-53. ISBN 960-86733-3-X
Betaine reduces the irritating effect of sodium lauryl sulphate on human oral mucosa in vivo abstractRantanen I, Nicander I, Jutila K, Ollmar S, Tenovuo J, Soderling E. Acta Odontol Scand 2002 Oct; 60(5): 306-10
Variation of skin properties within human forearms demonstrated by non-invasive detection and multi-way analysis abstractÅberg P, Geladi P, Nicander I, Ollmar S. Skin Res Technol 2002; 8: 194-201
Urea and sodium chloride in moisturisers for skin of the elderly – a comparative, double-blind, randomised study abstract, Kuzmina N, Hagstromer L, Emtestam L. Skin Pharmacol Appl Skin Physiol 2002; 15: 166-174
Skin Sensitivity Testing – A Biophysical Approach ThesisNyrén M. Karolinska Institutet, Stockholm 2002Do urea and sodium chloride together increase the efficacy of moisturizers for atopic dermatitis skin? abstract, Hagströmer L, Nyren M, Emtestam L. Skin Pharmacol Appl Skin Physiol 2001; 14: 27-33
Instrumental measurement of the Mantoux test: Differential effects of tuberculin and sodium lauryl sulphate on impedancve response patterns in human skin abstract, Nyrén M, Hagströmer L, Emtestam L. Dermatology 2000; 201: 212-217
Electrical impedance measurements at different skin sites related to seasonal variations abstract, Nicander I, Ollmar S. Skin Res Technol 2000; 6: 81-86
Making electronic biopsies into a viable future for non-invasive diagnostics with electrical impedance,Ollmar S. Med Biol Eng Comp 1999; 37, Suppl 2: 116-117
Electrical impedance related to structural differences in the skin and in the oral mucosa,Nicander I, Ollmar S. Med Biol Eng Comp 1999; 37, Suppl 1: 161-162
Electrical Bio-Impedance related to structural differences and reactions in skin and oral mucosa abstract,Nicander I, Ollmar S. Annals of the New York Academy of Sciences 1999; 873: 221-226
Inter- and intra-individual differences in human stratum corneum lipid content related to physical parameters of skin barrier function in vivo abstract,Norlen L, Nicander I, Lundh Rozell B, Ollmar S, Forslind B. J Invest Dermatol. 1999 Jan;112(1):72-7.
Electrical impedance related to experimentally induced changes of human skin and oral mucosa ThesisNicander I. Karolinska Institutet, Stockholm, 1998
Multivariate analysis of skin impedance data in long-term type 1 diabetic patients abstract,Lindholm-Sethson B, Han S, Ollmar S, Nicander I, Jonsson G, Lithner F, Bertheim U, Geladi P. Chemometrics and Intelligent Laboratory Systems 1998; 44: 381-394
Electrical impedance and other physical parameters as related to lipid content of human stratum corneumNicander I, Norlén L, Brockstedt U, Lundh Rozell B, Forslind B, Ollmar S. Skin Res Technol 1998; 4: 213-221
Methods of information extraction from impedance spectra of biological tissue, in particular skin and oral mucosa – a critical review and suggestions for the future,Ollmar S. Bioelectrochemistry & Bioenergetics 1998; 45: 157-160
Lipid content and electrical impedance abstract,Nicander I, Norlén L, Forslind B, Ollmar S. Curr Probl Dermatol. Basel, Karger, 1998, vol 26, pp 165-176
Electrical impedance for quantification and classification of experimental skin reactions abstract Emtestam L, Nyrén M. Am J Contact Dermatitis 1997; 8 (4): 202-206
Electrical impedance. A method to evaluate subtle changes of the human oral mucosa abstract Nicander I, Lundh Rozell B, Rundquist L, Ollmar S. Eur J Oral Sci 1997; 105: 576-582
Mild and below threshold skin responses to sodium lauryl sulphate assessed by depth controlled electrical impedance Nicander I, Ollmar S. Skin Res Technol 1997; 3: 259-263
Baseline electrical impedance measurements at various skin sites, related to age and sex Nicander I, Nyrén M, Emtestam L, Ollmar S. Skin Res Technol 1997; 3: 252-258
Information in full and reduced data sets of electrical impedance spectra from various skin conditions compared by using a holographic neural network abstractOllmar S, Nicander I, Ollmar J, Emtestam L. Med Biol Eng Comput 1997; 35: 415-419
Allergic contact reactions in the skin assessed by electrical impedance – a pilot studyNicander I, Ollmar S, Lundh Rozell B, Emtestam L. Skin Res Technol 1997; 3: 121-125
Electric impedance measurements at six different anatomic locations of macroscopically normal human oral mucosa abstract Nicander I, Rundquist L, Ollmar S. Acta Odontol Scand 1997; 55: 88-93
Instrumental evaluation of skin irritation. Rizwi PY, Morrison BM, Grove MJ, Grove GL. Cosmetics & Toiletries mag 1996; 111, Sept: 39-42
An electrical impedance technique for assessment of wheals abstractNyrén M, Ollmar S, Nicander I, Emtestam L. Allergy 1996; 51: 923-926Interpretation of impedance data of stripped skin supported by histological findings Nicander I, Lundh Rozell B, Emtestam L, Ollmar S. Med Biol Eng Comput 1996; 34, Supplement 1, Part 2: 147-148
Quantification of skin and mucosal reactions by electrical impedanceOllmar S. Med Biol Eng Comput 1996; 34, Supplement 1, Part 2: 145-146
Correlation of impedance response patterns to histological findings in irritant skin reactions induced by various surfactants abstract Nicander I, Ollmar S, Eek A, Lundh Rozell B, Emtestam L. Br J Dermatology 1996; 134: 221-228
Information in multi frequency measurement of intact skinOllmar S, Nicander I. Innov Tech Biol Med 1995; 16: 745-751
Electrical impedance measured to five skin depths in mild irritant dermatitis induced by sodium lauryl sulphate abstractNicander I, Ollmar S, Lundh-Rozell B, Eek A, Emtestam L. British J Dermatology 1995; 132: 718-724
Electrical impedance for estimation of irritation in oral mucosa and skin abstractOllmar S, Eek A, Sundström F, Emtestam L. Med Progr Techn 1995; 21: 29-37
Electrical impedance spectroscopy detects skin barrier dysfunction in childhood atopic dermatitis, Mari Sasaki, Mathilda Sundberg, Remo Frei, Ruth Ferstl, Kristina N. Heye, Erik P. Willems, Cezmi A. Akdis, Roger Lauener, CK-CARE Study Group, Caroline Roduit. https://onlinelibrary.wiley.com/doi/full/10.1111/all.15895
Household laundry detergents disrupt barrier integrity and induce inflammation in mouse and human skin, Arturo O. Rinaldi, Manru Li, Elena Barletta, Paolo D’Avino, Duygu Yazici, Yagiz Pat, Siobhan Ward, Daniel Burla, Ge Tan, Nima Askary, Rasmus Larsson, Jeremy Bost, Huseyn Babayev, Raja Dhir, Nicolas Gaudenzio, Mubeccel Akdis, Kari Nadeau, Cezmi A. Akdis, Yasutaka Mitamura,https://onlinelibrary.wiley.com/doi/full/10.1111/all.15895
Electrical impedance spectroscopy for the characterization of skin barrier in atopic dermatitis, Rinaldi, Korsfeldt, Ward, Burla, Dreher, Gautschi, Stolpe, Tan, Bersuch, Melin, Askary Lord, Grant, Svedenhag, Tsekova, Schmid‐Grendelmeier, Möhrenschlager, Renner, Akdis, European Journal of Allergy and Clinical Immunology, April 2021, https://doi.org/10.1111/all.14842
Skin hydration dynamics investigated by electrical impedance techniques in vivo and in vitro Morin, Ruzgas, Svedenhag, Anderson, Ollmar, Engblom, Björklund, Scientific reports Oct 2020 10:17218, doi.org/10.1038/s441598-020-73684-y
Electrical Impedance Spectroscopy as a safe and efficient tool for the evaluation of epithelial barrier, Rinaldi AO, Ward S, Burla D, Gautschi M, Stolpe B, Johansson A, Melin D, Grant S, Svedenhag P, Tsekova K, Möhrenschlager M, Renner E, Akdis C. , e-Poster Gordon Research Conference Jan 2020
Direct Assessment of skin epithelial barrier by electrical impedance spectroscopy, Rinaldi AO, Morita H, Wawrzyniak P, Dreher A, Grant S, Svedenhag P, Akdis CA, Allergy 2019 Apr 16, DOI: 10.1111/all.13824
Facts and artefacts regarding correlation between skin electrial impedance spectroscopy (EIS) and blood glucose Ollmar S, Nicander I, Åberg P, Bolinder J. XV Int. Conf. on Electrical Bio-Impedance & XIV Conf. on Electrical Impedance Tomography. IOP Publishing, Journal of Physics: Conference Series 434 (2013) 012071.
Bioimpedance as a noninvasive method for measuring changes in skinÅberg P, Nicander I, Ollmar S. XV In: Handbook of Non-Invasive Methods and the Skin, 2nd ed – pp 345-350. Serup, Jemec, Grove. CRC Press 2006.
Within and beyond the skin barrierOllmar S, Nicander I. In: Bioengineering of the skin – Water and the stratum corneum, 2nd ed., pp 335-350. Fluhr, Elsner, Berardesca, Maibach (Eds.). CRC Press 2005.
Effects of pretreatment with a urea-containing emollient on nickel allergic skin reactions abstract, Kuzmina N, Nyrén M, Lodén M, Edlund F, Emtestam L. Acta Dermato-Venereologica 2005; 85: 9-12
Effects of pre-treatment with a urea-containing emollient on nickel allergic skin reactions Kuzmina N, Nyrén M, Lodén M, Edlund F, Emtestam L, Nicander I, Ollmar S. Proc XII Intern Conf on Electrical Bio-Impedance & V Electrical Impedance Tomography, Gdansk (PL), June 20-24, 2004, 111-113. ISBN 83-917681-6-3
Skin bioimpedance, Ollmar S, Nicander I, Åberg P. Proc XII Intern Conf on Electrical Bio-Impedance, Gdansk (PL), June 20-24, 2004, 343-346. ISBN 83-917681-6-3>br>
Blood glucose modulates impedance levelBirgersson U, Neiderud F, Åberg P, Ollmar S. Proc XII Intern Conf on Electrical Bio-Impedance & V Electrical Impedance Tomography, Gdansk (PL), June 20-24, 2004, 153-156. ISBN 83-917681-6-3.
Biophysical aspects of contact dermatitis and its prevention abstract, Kuzmina N. Karolinska Institutet (thesis), Stockholm 2004
Clinically normal atopic skin versus non-atopic skin as seen through electrical impedance abstract, Nicander I, Ollmar S. Skin Res Technol 2004; 10: 178-183
Assessment of irritant skin reactions using electrical impedance – a comparison between 2 laboratories abstractKuzmina N, Duval C, Johnsson S, Boman A, Lindberg M, Emtestam L. Contact dermatitis 2003; 49(1): 26-31
Basal electrical impedance in relation to sodium lauryl sulphate-induced skin reactions – a comparison of patients with eczema and healthy controls abstractKuzmina N, Hagströmer L, Nyrén M, Emtestam L. Skin Res Technol 2003; 9: 357-362
Betaine in oral hygiene with special attention to dry and sensitive mucosa (thesis), Rantanen I. Annales Universitatis Turkuensis 559, Turku, Finland 2003
The effects of two sodium lauryl sulphate-containing toothpastes with and without betaine on human oral mucosa in vivo abstract, Rantanen I, Jutila K, Nicander I, Tenovuo J, Söderling E. Swed Dent J 2003; 27: 31-34
Electrical impedance as a potential tool to distinguish between allergic and irritant contact dermatitis abstract, Nyren M, Kuzmina N, Emtestam L. J Am Acad Dermatol 2003;48: 394-400
The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively abstract, Nicander I, Åberg P, Ollmar S. Skin Res Technol 2003; 9: 43-49
The ability of betaine to reduce the irritating effects of detergents assessed visually, histologically and by bioengineering methods abstract, Nicander I, Rantanen I, Lundh Rozell B, Söderling E, Ollmar S. Skin Res Technol 2003; 9: 50-58
Non-invasive detection of sub-clinical skin reactionsOllmar S. Proc of the 2nd International Workshop on Biological Effects of Electromagnetic Fields, Rhodes (GR), 7-11 Oct 2002, vol I: 46-53. ISBN 960-86733-3-X
Betaine reduces the irritating effect of sodium lauryl sulphate on human oral mucosa in vivo abstractRantanen I, Nicander I, Jutila K, Ollmar S, Tenovuo J, Soderling E. Acta Odontol Scand 2002 Oct; 60(5): 306-10
Variation of skin properties within human forearms demonstrated by non-invasive detection and multi-way analysis abstractÅberg P, Geladi P, Nicander I, Ollmar S. Skin Res Technol 2002; 8: 194-201
Urea and sodium chloride in moisturisers for skin of the elderly – a comparative, double-blind, randomised study abstract, Kuzmina N, Hagstromer L, Emtestam L. Skin Pharmacol Appl Skin Physiol 2002; 15: 166-174
Skin Sensitivity Testing – A Biophysical Approach ThesisNyrén M. Karolinska Institutet, Stockholm 2002Do urea and sodium chloride together increase the efficacy of moisturizers for atopic dermatitis skin? abstract, Hagströmer L, Nyren M, Emtestam L. Skin Pharmacol Appl Skin Physiol 2001; 14: 27-33
Instrumental measurement of the Mantoux test: Differential effects of tuberculin and sodium lauryl sulphate on impedancve response patterns in human skin abstract, Nyrén M, Hagströmer L, Emtestam L. Dermatology 2000; 201: 212-217
Electrical impedance measurements at different skin sites related to seasonal variations abstract, Nicander I, Ollmar S. Skin Res Technol 2000; 6: 81-86
Making electronic biopsies into a viable future for non-invasive diagnostics with electrical impedance,Ollmar S. Med Biol Eng Comp 1999; 37, Suppl 2: 116-117
Electrical impedance related to structural differences in the skin and in the oral mucosa,Nicander I, Ollmar S. Med Biol Eng Comp 1999; 37, Suppl 1: 161-162
Electrical Bio-Impedance related to structural differences and reactions in skin and oral mucosa abstract,Nicander I, Ollmar S. Annals of the New York Academy of Sciences 1999; 873: 221-226
Inter- and intra-individual differences in human stratum corneum lipid content related to physical parameters of skin barrier function in vivo abstract,Norlen L, Nicander I, Lundh Rozell B, Ollmar S, Forslind B. J Invest Dermatol. 1999 Jan;112(1):72-7.
Electrical impedance related to experimentally induced changes of human skin and oral mucosa ThesisNicander I. Karolinska Institutet, Stockholm, 1998
Multivariate analysis of skin impedance data in long-term type 1 diabetic patients abstract,Lindholm-Sethson B, Han S, Ollmar S, Nicander I, Jonsson G, Lithner F, Bertheim U, Geladi P. Chemometrics and Intelligent Laboratory Systems 1998; 44: 381-394
Electrical impedance and other physical parameters as related to lipid content of human stratum corneumNicander I, Norlén L, Brockstedt U, Lundh Rozell B, Forslind B, Ollmar S. Skin Res Technol 1998; 4: 213-221
Methods of information extraction from impedance spectra of biological tissue, in particular skin and oral mucosa – a critical review and suggestions for the future,Ollmar S. Bioelectrochemistry & Bioenergetics 1998; 45: 157-160
Lipid content and electrical impedance abstract,Nicander I, Norlén L, Forslind B, Ollmar S. Curr Probl Dermatol. Basel, Karger, 1998, vol 26, pp 165-176
Electrical impedance for quantification and classification of experimental skin reactions abstract Emtestam L, Nyrén M. Am J Contact Dermatitis 1997; 8 (4): 202-206
Electrical impedance. A method to evaluate subtle changes of the human oral mucosa abstract Nicander I, Lundh Rozell B, Rundquist L, Ollmar S. Eur J Oral Sci 1997; 105: 576-582
Mild and below threshold skin responses to sodium lauryl sulphate assessed by depth controlled electrical impedance Nicander I, Ollmar S. Skin Res Technol 1997; 3: 259-263
Baseline electrical impedance measurements at various skin sites, related to age and sex Nicander I, Nyrén M, Emtestam L, Ollmar S. Skin Res Technol 1997; 3: 252-258
Information in full and reduced data sets of electrical impedance spectra from various skin conditions compared by using a holographic neural network abstractOllmar S, Nicander I, Ollmar J, Emtestam L. Med Biol Eng Comput 1997; 35: 415-419
Allergic contact reactions in the skin assessed by electrical impedance – a pilot studyNicander I, Ollmar S, Lundh Rozell B, Emtestam L. Skin Res Technol 1997; 3: 121-125
Electric impedance measurements at six different anatomic locations of macroscopically normal human oral mucosa abstract Nicander I, Rundquist L, Ollmar S. Acta Odontol Scand 1997; 55: 88-93
Instrumental evaluation of skin irritation. Rizwi PY, Morrison BM, Grove MJ, Grove GL. Cosmetics & Toiletries mag 1996; 111, Sept: 39-42
An electrical impedance technique for assessment of wheals abstractNyrén M, Ollmar S, Nicander I, Emtestam L. Allergy 1996; 51: 923-926Interpretation of impedance data of stripped skin supported by histological findings Nicander I, Lundh Rozell B, Emtestam L, Ollmar S. Med Biol Eng Comput 1996; 34, Supplement 1, Part 2: 147-148
Quantification of skin and mucosal reactions by electrical impedanceOllmar S. Med Biol Eng Comput 1996; 34, Supplement 1, Part 2: 145-146
Correlation of impedance response patterns to histological findings in irritant skin reactions induced by various surfactants abstract Nicander I, Ollmar S, Eek A, Lundh Rozell B, Emtestam L. Br J Dermatology 1996; 134: 221-228
Information in multi frequency measurement of intact skinOllmar S, Nicander I. Innov Tech Biol Med 1995; 16: 745-751
Electrical impedance measured to five skin depths in mild irritant dermatitis induced by sodium lauryl sulphate abstractNicander I, Ollmar S, Lundh-Rozell B, Eek A, Emtestam L. British J Dermatology 1995; 132: 718-724
Electrical impedance for estimation of irritation in oral mucosa and skin abstractOllmar S, Eek A, Sundström F, Emtestam L. Med Progr Techn 1995; 21: 29-37
Supporting research and innovation
Nevisense is increasingly used in academic studies focused on skin health, barrier function and the effects of dermatological treatments. Research groups value its repeatability, non-invasiveness and quantitative data output.
Used by leading institutions
Hospitals, dermatology clinics and research centers in Germany, the US and other countries have integrated Nevisense into their workflows – citing improved diagnostic decision-making and streamlined patient care.
Validated in the largest study of its kind
The clinical performance of Nevisense was validated in a pivotal prospective study involving 1,951 patients and 265 melanomas—the largest study of its kind conducted in melanoma detection. The study demonstrated 97% sensitivity and a 99% negative predictive value, providing robust evidence for the use of Nevisense as an adjunct to clinical and dermoscopic evaluation.
Get in touch
Would you like to learn more about the clinical evidence behind Nevisense or how it can support your practice? Contact the SciBase team!