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Skin Cancer Research

Melanoma and keratinocyte cancer research with the Nevisense EIS technology

Explore clinical research on Nevisense in skin cancer detection. These studies examine how electrical impedance spectroscopy (EIS) can support the assessment of suspicious lesions, including melanoma and keratinocyte cancers.

Rooted in academic research

 Nevisense originated from research at Karolinska Institutet in Sweden. Today, the technology is supported by a growing body of clinical evidence and used in clinical practice, dermatological research, and product development worldwide. 

Research with the Nevisense EIS Technology

  • Comparing Improvements in Biopsy Decision Making with Electrical Impedance Spectroscopy Between US and German Dermatologists, D Zakria, N Brownstone, M Shah, MD3, J Burshtein, L DeBusk, A Rosenberg, D Rigel, SKIN Jan 2025, Vol 9 Issue 1, DOI https://doi.org/10.25251/skin.9.1.5
  • Advances in Technology for Melanoma Diagnosis and Prognosis: En Expert Consensus Panel, J Burshtein, D Zakria, B Berman, S Desai, A Farberg, G Goldenberg, B Glick, M Nestor, K Nouri, T Rosen, M Lebwohl, D Rigel, JDD Sep 24, Vol 23 Issue 9, 774 DOI: 10.36849/JDD.8365R1
  • Utilizing Data from Electrical Impedance Spectroscopy Significantly Improves the Decision to Biopsy Pigmented Skin Lesions Beyond Clinical Evaluation and Dermoscopy, D Zakria, N Brownstone, K Fritz, C Salavastru, D Rigel SKIN May 2024, Volume 8, Issue 3, DOI https://doi.org/10.25251/skin.8.3.5
  • Management of Pigmented Lesions in Primary Care: Effects of Electrical Impedance Spectroscopy Use, Shayan Owji, Joseph Han, Margaret Glausser, Daniel Napolitano and Jonathan Ungar, The Annals of Family Medicine January 2023, 21 (Supplement 1) 4189; DOI: https://doi.org/10.1370/afm.21.s1.4189
  • 2022 Zakria, Electrical impedance spectroscopy significantly enhances correct biopsy choice for pigmented skin lesions beyond clinical evaliation and dermoscopy, D Zakria, N Brownstone, J Han, S Owji, M Dirr, D Rigel, Melanoma Research Oct 2022, DOI: 10.1097/CMR.0000000000000859 https://jofskin.org/index.php/skin/article/view/1568
  • Diagnostic Efficiacy of Electrical Impedance Spectroscopy versus Dermoscopy for Pigmented Skin Lesions: A pilot study, S Owji, J Han, H He, I Lopera, M Tassavor, N Brownstone, N Gulati, B Ungar, J Ungar, SKIN May 2022, Vol 6, Issue 3
    https://jofskin.org/index.php/skin/article/view/1568
  • Electrical Impedance Spectroscopy improves skin cancer detection and reduces the number of biopsies, C. Liebich, J. Bartsch, I. Schubert, M-L. v. Bruehl, C. Sander, Dermato, 2022, 2, 21-29. DOI.org/10.3390/dermato2020004
  • Impact of Electrical Impedance Spectroscopy on Clinician Confidence and Diagnostic Accuracy in Evaluating Melanocytic Skin Lesions Suspicious for Melanoma: A Pilot Study, A. Kolla, L. Fried, P. Shah, T. Liebman, J. Stein, D. Polsky, SKIN January 2022 Vol6, Issue doi.org/10.25251/skin.6.1.4
  • Impact of Electrical Impedance Spectroscopy on Dermatologists’ Number-Needed-to-Biopsy Metric and Biopsy Decisions for Pigmented Skin Lesions, G. Litchman, R Teplitz, J. Marson, D Rigel, JAAD October 2021, doi.org/10.1016/j.jaad.2020.09.011
  • Retrospective evaluation of the performance of the electrical impedance spectroscopy system Nevisense in detecting keratinocyte cancers, C. Liebich, M-L Bruehl, I Schubert, R Oberhoffer, C Sander, Skin Research and Technology, 2021;00:1-7; DOI:10.1111/srt.13007
  • Diagnostic Accuracy of Electrical Impedance Spectroscopy in Non-melanoma Skin Cancer, E Sarac, C Garbe et. al, DOI: 10.2340/00015555-3689, Acta Derm Venereol 2020; 100: adv00328
  • Electrical Impedance Spectroscopy: Augmented Intelligence Technology for the Early Detection of Melanoma, G Goldenberg, Practical Dermatology April 2020, p44-45.
  • Impact of Electrical Impedance Spectroscopy on Dermatologists’ Number-Needed-to-Biopsy Metric and Biopsy Decisions for Pigmented Skin Lesions. Litchman, D Rigel et al ,https://doi.org/10.1016/j.jaad.2020.09.011
  • Integrating Electrical Impedance Spectroscopy into Clinical Decisions for Pigmented Skin Lesions Improves Diagnostic Accuracy: A Multitiered Study, G Litchman, D Rigel et al, SKIN July 2020 Volume 4, Issue 4
  • Integrating Electrical Impedance Score into Decision to Biopsy Increases Biopsy Efficiency,
    G Prado, D Rigel, ePoster 10062, AAD 2019, www.aad.org/eposters/Submissions/getFile.aspx?id=10062&type=sub
  • Electrical impedance spectroscopy of 79 melanocytic lesions in a National Health Service skin cancer clinic, Haddadeen C.; Maguire C.; Henderson C. 99th Annual Meeting of the British Association of Dermatologists, conference abstract, British Journal of Dermatology 181 Supplement 1 (62-63). 2019, http://dx.doi.org/10.1111/bjd.17893
  • Electrical Impedance Spectroscopy Improves Diagnostic Accuracy of Pigmented Lesions,
    G Prado, D Rigel et al, ePoster 10229, AAD 2019, www.aad.org/eposters/Submissions/getFile.aspx?id=10229&type=sub
  • EIS: Atypien von Hautveränderungen präzise messen,
    J Welzel, U Reinhold, Der Deutsche Dermatologe 2018 Nov, pages 847-851, DOI: 10.1007/s15011-018-2189-3
  • Assessment of Clinician Accuracy for Diagnosing Melanoma Based on Electrical Impedance Spectroscopy Score Plus Morphology Versus Lesion Morphology Alone, abstract,
    R Svoboda, G Prado, R Mirsky, D Rigel, JAAD 2018. DOI: 10.1016/j.jaad.2018.08.048
  • Electrical Impedance Spectroscopy Versus Clinical Inspection Approaches: Melanoma Efficacy Detection Comparison, abstract,
    R Svoboda, A Franco, D Rigel, SKIN 2018, DOI: 10.25251/skin.2.3.2
  • Noninvasive diagnosis in dermatology, abstract,
    J Welzel, S Schuh, JDDG 2017 999-1016, DOI: 10.1111/ddg.13347
  • Electrical Impedance Spectroscopy in Skin Cancer Diagnosis Abstract
    R Braun, J Mangana, S Goldinger, Lars French, R Dummer, A Marghoob, Dermatological Clinic 35 (2017) 489-493, http://dx.doi.org/10.1016/j.det.2017.06.009
  • Utilisation of an Electrical Impedance Spectroscopy System in an NHS setting in a pigmented lesion clinic as an adjuvant to dermoscopy and clinical history
    Catriona Henderson, Birgit Pees, Poster the 97th Annual Meeting of the British Association of Dermatologists in Liverpool July 4-6 2017
  • Analysis of an electrical impedance spectroscopy system in short-term digital dermoscopy imaging of melanocytic lesions full article
    Rocha, S.W. Menzies, S. Lo, M. Avramidis, R. Khoury, L. Jackett, P.Guitera. British Journal of Dermatology. 19 April 2017. DOI: 10.1111/bjd.15595
  • Nevisense: Improving the accuracy of diagnosing melanoma, Ollmar S.; Grant S, Melanoma Management (2016) 3:2 (93-96). http://dx.doi.org/10.2217/mmt-2015-0004
  • Practical application of new technologies for melanoma diagnosis: Part I. Noninvasive approaches March, Hand, Grossman, Journal of the American Academy of Dermatology (2015) 72:6 (929-941). DOI:/10.1016/j.jaad.2015.02.1138
  • Clinical performance of the Nevisense system in cutaneous melanoma detection: an international, multi-centre, prospective and blinded clinical trial on efficacy and safety full article
    Malvehy J, Hauschild A, Curiel-Lewandrowski C, Mohr P, Hofmann-Wellenhof R, Motley R, Berking C, Grossman D, Paoli J, Loquai C, Olah J, Reinhold U, Wenger H, Dirschka T, Davis S, Henderson C, Rabinovitz H, Welzel J, Schadendorf D, Birgersson U. British Journal of Dermatology. 2014 May 19. DOI: 10.1111/bjd.13121.
  • Electrical Impedance Spectroscopy as a potential adjunct diagnostic tool for cutaneous melanoma full article
    Mohr P, Birgersson U, Berking C, Henderson C, Trefzer U, Kemeny L, Sunderkötter C, Dirschka T, Motley R, Frohm-Nilsson M, Reinhold U, Loquai C, Braun R, Nyberg F, Paoli J. Skin Res Technol. 2013 Jan 27. doi: 10.1111/srt.12008.
  • Electrical impedance of human skin and tissue alterations: Mathematical modeling and Measurements thesis
    Birgersson U. Karolinska Institutet (thesis), Stockholm 2012.
  • Electrical impedance and the diagnostic accuracy for malignant melanoma abstract
    Åberg P, Birgersson U, Elsner P, Mohr P, Ollmar S. Experimental Dermatology, 2011 Mar 3; 648-652.
  • Non-invasive and microinvasive electrical impedance spectra of skin cancer – a comparison between two techniques abstract Åberg P, Geladi P, Nicander I, Hansson J, Holmgren U, Ollmar S. Skin Res Technol. 2005 Nov;11(4):281-6.
  • Skin cancer as seen by electrical impedance thesis
    Åberg P. Karolinska Institutet (thesis), Stockholm 2004.
  • Bioimpedance of different skin tumours – clinical tricks and treats
    Nicander I, Holmgren U, Åberg P, Ollmar S. Proc XII Intern Conf on Electrical Bio-Impedance & V Electrical Impedance Tomography, Gdansk (PL), June 20-24, 2004, 99-102. ISBN 83-917681-6-3
  • Skin bioimpedance – electronic views of malignancies
    Åberg P, Nicander I, Hansson J, Holmgren U, Ollmar S. Proc XII Intern Conf on Electrical Bio-Impedance & V Electrical Impedance Tomography, Gdansk (PL), June 20-24, 2004, 79-82. ISBN 83-917681-6-3
  • Skin cancer identification using multi-frequency electrical impedance – a potential screening tool abstract
    Åberg P, Nicander I, Hansson J, Geladi P, Holmgren U, Ollmar S. IEEE Trans Biomed Eng 2004; 51(12): 2097-2102
  • Detection of basal cell carcinoma using electrical impedance and neural networks abstract
    Dua R, Beetner DG, Stoecker WV, Wunsch DC. IEEE Trans Biomed Eng 2004; 51(1): 66-71
  • Minimally invasive electrical impedance spectroscopy of skin exemplified by skin cancer assessments
    Åberg P, Nicander I, Ollmar S. In: Proc IEEE EMBS, Cancun (MX), 17-21 Sept 2003, 3211-3214, ISBN 0-7803-7790-7
  • Differentiation among basal cell carcinoma, benign lesions, and normal skin using electric impedance abstract
    Beetner DG, Kapoor S, Manjunath S, Zhou X, Stoecker WV. IEEE Trans Biomed Eng 2003; 50(8): 1020-1025
  • Assessment of skin lesions and skin cancer using simple electrical impedance indices abstract
    Åberg P, Nicander I, Holmgren U, Geladi P, Ollmar S. Skin Res Technol 2003; 9: 257-261
  • Electrical impedance of nodular basal cell carcinoma: a pilot study abstract
    Emtestam L, Nicander I, Stenström M, Ollmar S. Dermatology 1998; 197: 313-316

Validated in the largest study of its kind

The clinical performance of Nevisense was validated in a pivotal prospective study involving 1,951 patients and 265 melanomas—the largest study of its kind conducted in melanoma detection. The study demonstrated 97% sensitivity and a 99% negative predictive value, providing robust evidence for the use of Nevisense as an adjunct to clinical and dermoscopic evaluation.

 

 

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